Gluteal Subcutaneous Atrophy After Depot Steroid Injection for Allergic Rhinitis

Allergic rhinitis is a common and often distressing condition. Currently, treatment with nonsedating antihistamines, topical therapy, and immunotherapy are very effective. Despite this, intramuscular depot steroids are commonly used in clinical practice. Here, we present the case of a young woman who developed disfiguring scarring after a depot steroid injection. This case highlights the risks of this form of treatment for allergic rhinitis.

Systemic steroids have played a role in the management of allergic rhinitis in the past 5 decades. Early reports confirmed an excellent response to systemic steroids. In recent years, the use of oral steroids has not been recommended for the management of allergic rhinitis in view of the efficacy of topical therapy and concerns about adverse effects.
However, oral and intramuscular depot steroids remain popular in primary care because of their efficacy and the expense of allergen-specific immunotherapy. Here, we present the case of a patient who suffered disfiguring subcutaneous atrophy in the gluteal region from a depot triamcinolone injection given for allergic rhinitis.

CASE REPORT
The patient is a 29-year-old immigrant. Shortly after moving to New Zealand, she suffered disabling allergic rhinitis symptoms. Her symptoms were perennial. She was clinically assessed by her family physician and was given a depot 40-mg triamcinolone injection into the gluteal region. She experienced rapid relief of her nasal obstruction and rhinorrhea. She had received prior injections of depot steroids for her rhinitis. Within a few weeks, she developed a large 5-cm scar at the injection site ( Figs. 1 and 2).
She was reviewed in the immunology clinic at the Auckland Hospital. Skin prick testing confirmed strongly positive reactions to dust mites. She was treated with a combination of loratadine 10 mg and Budesonide 100 mg nasal spray twice daily. She declined the offer of immunotherapy on account of expense. She was reviewed by a plastics and reconstructive surgeon, but no operative intervention was offered.

DISCUSSION
Depot steroid injections for seasonal allergic rhinitis have been commonly used in some parts of the world, particularly Denmark. One study estimated that 0.66% of the entire Danish population received depot steroid injections each year. 2 The efficacy of depot steroid injections has been established in several randomized controlled trials. 3 Depot steroids appear to be more effective than topical beclomethasone 4 and are as effective as 7.5 mg of oral prednisone given for 3 weeks. 5 Most patients experience 4 to 5 weeks of symptoms relief after a single injection.
Generally, nasal obstruction is more likely to improve than rhinorrhea or sneezing. It is of interest that most of these The author has no funding or conflicts of interest to disclose. Correspondence to: Rohan Ameratunga, MBChB, Clinical Immunologist, Auckland Hospital, Park Road, Grafton, Auckland 1023, New Zealand. Telephone: 64-9-3797-440 (ext: 6113). Fax: 64-9-307-2826. E-mail: rohana@ahdb.govt.nz. Copyright Ó 2012 by World Allergy Organization randomized trials of depot steroids were undertaken in Denmark. All these randomized trials of depot steroids for allergic rhinitis were undertaken before 1988. It was around this time that effective nonsedating antihistamines became widely available.
In recent years, there has been increasing concern about the use of depot steroids in the management of allergic rhinitis. 6 Patients with severe symptoms unresponsive to antihistamines and topical steroid therapy should be referred to an allergy specialist for consideration of immunotherapy. 7 The lack of allergy services in many parts of the world, including New Zealand, has hindered such referrals. 8 Although relatively uncommon, adverse effects from depot steroids are a source of increasing concern. Bilateral avascular necrosis after a depot steroid injection has been reported. 8 There is concern about hypothalamic pituitary adrenal axis suppression and long-lasting effects on bone mineral density. 6 Subcutaneous atrophy of the deltoid has been described after depot steroid injections for allergic rhinitis. This has been termed pseudomorphea. 9 One case of subcutaneous atrophy has been estimated to occur after 11,000 injections. 2 Although this may be a rare event, there is concern about underreporting. 6 In some patients, the area of scarring improves slowly after several years. This case illustrates the small but significant risk of using this form of treatment for a non-life-threatening disorder. Before this case, it was previously thought that intramuscular injections into the gluteal region were associated with a low risk of subcutaneous atrophy. 2 It is uncertain if this patient received an intramuscular injection or whether the triamcinolone was injected into the subcutaneous tissues.
Depot steroid injections remain very poplar among primary care physicians and patients. Their low cost and effectiveness underscore this popularity. The pressure to use this form of treatment should be resisted given the small but significant risk of disfiguring adverse effects.
A short course of oral steroids could be justified for patients attending an important function such as a wedding or before surgery in unresponsive patients. Given the availability of effective therapy, depot steroid injections should be considered an obsolete form of treatment for allergic rhinitis. This from of treatment, particularly repeated doses, should no longer be accepted as the standard of care of allergic rhinitis. 10