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Local cytokine profile as an effective inflammation control tool among patients, suffering from bronchial asthma and various allergic rhinitis phenotypes

      Introduction

      Mixed inflammation characteristics on lower and upper airways mucosa among certain patients conditions inflammatory process specifics and BA flow, mixed with various allergic rhinitis types. Control effectiveness depends on timely inflammatory process activity evaluation. Local cytokine profile parameters research allows not only control inflammation and assess therapy effectiveness among such patients, but also timely prevent pathology severeness increase and complications formation.

      Materials and Methods

      Research method was as follows: key cytokines local fracture assessment using immunoenzymatic approach – IL-2, IL-4, IL-8, IL-10, γ – INF, α-TNF in nasal lavage among 57 patients in non-exacerbation period, suffering from BA and various perennial allergic rhinitis phenotypes. Research also included 21 patient, suffering from comorbid vascular dystonia, 25 patients, suffering from comorbid herpetic viral infection. Control group consisted of 11 patients without any comorbid pathology.

      Results

      Control group patients show reliable IL-10 and γ – INF content change in nasal secret. Patients, suffering from comorbid herpetic viral infection showed rapid γ – INF content decrease, IL-8 production increase and α-TNF content changes in herpetic viral infection exacerbation period. Patients, associated to vascular dystonia, showed IL-2 and IL-8 level change.

      Conclusions

      Local nasal mucosa inflammatory process pathogenesis is an effective inflammation control biomarker not only for various allergic rhinitis phenotypes, but also for patients, suffering from BA and various allergic rhinitis phenotypes. Alongside with effectiveness, simplicity and non-invasive character this method is economically attractive, which is the sufficient reason to include it in recommendations on treatment of patients, suffering from BA, mixed with various allergic rhinitis phenotypes.